[遺] 同源重組
The structure is closely related with homologous chromosomes synapsis, recombination and segregation.
它與同源染色體聯會、遺傳交換、染色體分離密切相關。
Objective To construct replication deficient recombinant adenovirus of human monocyte chemoattractant protein-1(MCP-1) by homologous recombination.
目的制備表達人單核細胞趨化蛋白-1（MCP-1）複制缺陷型重組腺病毒。
Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining.
目前已鑒定的這一基因家族的多數成員均參與幾種重要的DNA修複途徑，包括堿基切除修複、同源重組修複和非同源末端重接。
We start with these fragments, and then we have a homologous recombination system that reassembles those into a chromosome.
我們以這些片段開始，然後通過同源重組将其組合到染色體中。
Structure formed during homologous recombination connection of single strands of one chromosome to the other chromosome .
在同源重組中一條染色體的單鍊與另一條染色體的單鍊連接形成的結構。
Consequence of homologous recombination, in which hybridization between different alleles causes one allele to be converted into the other.
同源重組的後果，在不同等位基因之間的雜交使其中的一個等位基因被轉換成了另一個等位基因。
Objective To construct recombinant adenovirus by homologous recombination in bacteria.
目的通過細菌内同源重組方法構建重組腺病毒。
Established upon the embryo stem cell technique and homologous recombination, gene targeting has been widely used in the genome specific manipulation.
基因打靶技術是建立在胚胎幹細胞和同源重組技術之上，可對基因組進行定點修飾的實驗方法。
Although it is very widely used in yeast and mouse embryonic stem cell, gene targeting is inefficient in plant because of low homologous recombination frequency.
基因定點突變與定點置換技術在酵母和小鼠胚胎幹細胞中已經比較成熟，但在高等植物中同源重組頻率非常低，限制了其使用。
Scientists know that homologous recombination repair is also required for the repair of DNA cross-links, but the exact details remain to be resolved, Chen said.
科學家知道，DNA交聯修複過程中也需要同源生物再結合修複參與，但是精确的細節仍有待研究。
Methods Homologous recombination method was used.
方法采用同源基因重組技術。
Objective To construct the recombinant adenovirus of human ICOS extracellular domain gene by using the method of homologous recombination in bacteria.
目的利用細菌内同源重組法構建含ICOS胞外區基因的重組腺病毒。
Homologous recombination would presumably be preferred in the case of more slowly-renewing tissues, whose stem cells should not need reseeding.
更新較緩慢的組織中，似應首選同源重組，因其幹細胞不需要種植。
The targeted integration mediated by the homologous recombination is the best strategy for human gene therapy, because the gene expression is controlled by the natural elements.
同源重組介導的基因靶向性整合，是遺傳性疾病基因治療的較佳方案。
Based on the homologous recombination, the plasmid pRG of reverse gyrase gene knock-out was constructed and transformed into the Sulfolobus islandicus and the single crossover mutant was isolated.
重組質粒反複轉化冰島硫化葉菌，得到質粒整合到宿主染色體上的單交換菌株，但沒有獲得反螺旋酶基因缺失的雙交換轉化子。
This study reports several significant evidence demonstrating that homologous recombination also takes place between influenza A viruses in human and swine lineages.
這項研究報告的一些重要證據表明A型流感病毒同源重組在人類和豬的譜系中發生。
In this experiment, DNA mismatch repair and homologous recombination repair as the two aspects of DNA repair system may play a role in the occurrence of endometrial adenocarcinoma development.
本實驗将從DNA錯配修複和同源重組修複這兩個方面探讨DNA修複系統在子宮内膜腺癌的發生發展中可能起到的作用。
Homologous recombination repair is a primary means for the repair of double-stranded DNA breaks (DSBs).
同源重組修複是一類重要的針對雙鍊DNA分子斷裂的修複方式。
Based on principle of homologous recombination, a new genetic engineering system named recombineering has been developed in recent years.
重組工程是近幾年來興起的一種基于體内同源重組的、新型的遺傳工程。
Most breaks are quickly and accurately fixed during the process of homologous recombination (HR), which uses an intact copy of DNA as a template for repair.
大多數斷裂在同源重組（HR）期間可快速而準确固定，它們可使用DNA完整拷貝作為修複模闆。
The homology region of gln gene which was used for the gene disruption by homologous recombination in the future study was constructed by the fusion PCR.
并利用融合PCR構建谷氨酰胺合成酶基因的同源片段，為進一步的通過同源重組替換谷氨酰胺合成酶基因實現基因敲除奠定基礎。
On the other hand, the successful rate of homologous recombination is increased to some extent.
同時也保證了較高的細菌内同源重組的成功率。
By analysis of the progeny of MAAL 11 using SSR markers, we found the mechanism of the introgression is happened through homologous recombination, although the recombination rate is relatively low.
通過分子标記分析，明确遠緣稻屬種間遺傳物質重組是通過有限的同源重組實現的。
同源重組（Homologous Recombination）是生物體内一種高度保守的DNA修複機制，指兩個相同或高度相似的DNA序列通過堿基配對實現遺傳信息精确交換的過程。該機制在維持基因組穩定性中起關鍵作用，主要發生于減數分裂時期的染色體交叉互換，以及體細胞DNA雙鍊斷裂修複過程中。
從分子機制分析，該過程涉及以下核心步驟：
臨床應用方面，美國國家癌症研究所（NCI）指出，BRCA1/BRCA2基因編碼的蛋白質正是參與同源重組修複的關鍵因子。這些基因的突變會導緻同源重組缺陷（HRD），顯著增加乳腺癌、卵巢癌等惡性腫瘤的發病風險。這一機制也為PARP抑制劑類靶向藥物（如奧拉帕尼）的研發提供了理論基礎。
現代生物技術中，冷泉港實驗室的研究證實，基于同源重組原理開發的CRISPR/Cas9基因編輯技術，能夠通過設計供體DNA實現基因組的精準修飾。這種技術在遺傳病治療、農作物改良等領域展現出重大應用價值。
Homologous Recombination（同源重組）是分子生物學和遺傳學中的核心概念，指DNA分子之間或内部基于同源序列的重新組合過程。以下為詳細解釋：
Homologous Recombination是依賴同源序列的DNA重組機制，對遺傳多樣性、DNA修複及生物進化具有重要意義。其過程涉及多種蛋白質複合物，且在真核與原核生物中存在保守性。
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