[内科] 全身性红斑狼疮
Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus.
血清蛋白氧化水平的提高与系统性红斑狼疮疾病活动度相关。
Four patients with systemic lupus erythematosus (SLE) who showed either minimal response or no further improvement to corticosteroids and immunosuppressive drugs, were treated with plasmapheresis.
四个全身性红斑狼疮（SLE）病人，因对皮质类固醇及免疫抑制剂治疗的效果不明显或不再进步而采用血浆换出治疗。
Objective To investigate the mechanism of Bugu capsules in the treatment of osteoporosis or bone loss in systemic lupus erythematosus(SLE) patients after long-term administration of glucocorticoid.
目的研究补骨胶囊防治系统性红斑狼疮（SLE）患者长期使用糖皮质激素治疗并发骨质疏松或骨量减少的作用机制。
Systemic lupus erythematosus (SLE) is a kind of autoimmunity disease caused by complicated factors.
系统性红斑狼疮是一种病因复杂的自身免疫性疾病。
Lupus band test and disease activity in systemic lupus erythematosus: Does it still matter?
系统性红斑狼疮的狼疮带试验与疾病活动性是否仍有关联?。
Objective To study the pregnancy opportunity, treatment of complications, time of ending pregnancy and treatment during and after pregnancy in patients with systemic lupus erythematosus(SLE).
目的探讨系统性红斑狼疮（SLE）患者的妊娠时机、妊娠期并发症处理、终止妊娠时机、分娩过程中及娩后治疗问题。
Systemic lupus erythematosus ( SLE ) is a multifactorial disease and its pathogenesis and precise mechanism remain unknown.
系统性红斑狼疮（SLE ）是一种多因素疾病，其病因和发病机制尚未明确。
In order to explore the inheritance mode of systemic lupus erythematosus(SLE), we analyzed 220 SLE pedigrees.
为探讨系统性红斑狼疮（SLE）的遗传方式，对220例SLE家系资料作了分析。
Systemic lupus erythematosus. This chronic inflammatory disease can lead to serious kidney damage.
系统性红斑狼疮 这种慢性炎性疾病会严重损害肾功能。
Objective To investigate the relationship between the peripheral blood lymphocyte subsets, disease activity and renal impairment in patients with systemic lupus erythematosus(SLE).
目的探讨系统性红斑狼疮（SLE）患者外周血淋T淋巴细胞亚群与病情活动性、肾脏损害的关系。
Detect the levels of dendritic cell subsets in systemic lupus erythematosus (SLE) patients, and study its correlation with SLE activity criteria.
目的检测系统性红斑狼疮患者树突状细胞亚型水平，探讨与疾病活动指数的相关性。
Objective:To detect the absolute numbers of peripheral blood dendritic cells(DC) subsets in systemic lupus erythematosus(SLE) patients, and analyze the correlation between the disease activity.
目的：检测系统性红斑狼疮（SLE）患者外周血中树突状细胞亚型绝对数，分析其与疾病活动程度的相关性。
Objective To delineate the immune regulatory pathway in pathogenesis of systemic lupus erythematosus (SLE) by using gene expression profile analysis.
目的通过基因表达谱勾画系统性红斑狼疮（SLE）发病机制中可能的免疫调控通路。
Objective To investigate the changes of interleukin 18(IL-18) levels in serum in patients with systemic lupus erythematosus(SLE) and its relationship with the activity of SLE.
目的探讨白细胞介素18（IL-18）在系统性红斑狼疮（SLE）患者血清中的水平变化及其与SLE活动性的关系。
Objective To evaluate the left ventricular long-axis systolic function in patients with early systemic lupus erythematosus(ESLE)with quantitative tissue velocity imaging(QTVI).
目的探讨应用定量组织速度成像（QTVI）技术评价早期系统性红斑狼疮（ESLE）患者左室长轴收缩功能的意义。
Objective To know the occurrence of activated protein C resistance (APCR) in Chinese patients with systemic lupus erythematosus (SLE) and investigate the occurring mechanism of thrombosis in SLE.
目的了解抗活化的蛋白C（APCR）在系统性红斑狼疮（SLE）患者中的发生情况，并进一步探讨SLE患者发生血栓的机制。
Objective To research the influence of B lymphocytes, T lymphocytes on systemic lupus erythematosus (SLE) patient′s and control′s granulocyte macrophage colony forming unit (GM CFU).
目的探讨系统性红斑狼疮（SLE）患者B、T淋巴细胞对SLE及正常人骨髓粒巨噬细胞集落形成单位（GMCFU）的影响。
Objective To discuss the feasibility and effect of labeled antibody on targeting therapy of systemic lupus erythematosus (SLE) associated thrombocytopenia.
目的：探讨药物标记抗体导向治疗系统性红斑狼疮（SLE）所致血小板减少的可行性及效果。
Objective To investigate the state of nosocomial bronchopulmonary infection(NBPI) in patients with systemic lupus erythematosus(SLE).
目的研究系统性红斑狼疮（SLE）患者医院获得性支气管-肺感染（NBPI）的状况。
Autoimmune diseases and collagen diseases, such as systemic lupus erythematosus, dermatomyositis, scleroderma, and so on.
自身免疫性疾病及胶原性疾病，如系统性红斑狼疮、皮肌炎、硬皮病等。
Objective To evaluate bone mineral density (BMD) in young ambulatory female patients with systemic lupus erythematosus (SLE) and to assess the influence of corticosteroids on BMD.
目的了解系统性红斑狼疮（SLE）患者骨矿物质密度（BMD）的变化，并讨论疾病的病情和激素对骨密度的影响。
Objective To study the effect of autologous peripheral blood stem cell transplantation(APBSCT) to the life quality of systemic lupus erythematosus(SLE) patients.
目的探讨自体外周血造血干细胞移植（APBSCT）对系统性红斑狼疮（SLE）患者生活质量的影响。
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterised by the mediation and the deposition of immune complexes in various tissues.
系统性红斑狼疮（SLE）是一种由免疫复合物介导和沉积引起的自身免疫性炎症性疾病。
OBJECTIVE To know the epidemiologic characteristics of systemic lupus erythematosus (SLE) patients with infection.
目的了解系统性红斑狼疮（SL E）患者并发感染的流行病学特征。
系统性红斑狼疮（Systemic Lupus Erythematosus，SLE）是一种慢性自身免疫性疾病，其特点是免疫系统错误攻击人体多个器官和组织的健康细胞，导致广泛炎症和器官损伤。该疾病名称中“系统性”指多系统受累，“红斑狼疮”源自拉丁语，描述患者面部典型的蝴蝶状红斑（形似狼咬伤）。
SLE的发病与遗传易感性、环境触发因素（如紫外线、病毒感染）和激素水平异常相关。患者体内产生大量自身抗体（如抗核抗体、抗双链DNA抗体），这些抗体与抗原结合形成免疫复合物，沉积在皮肤、关节、肾脏等部位，引发补体激活和炎症反应（来源：Mayo Clinic）。
疾病表现具有高度异质性，常见症状包括：
依据2019年EULAR/ACR分类标准，需满足至少1项临床标准（如狼疮肾炎、皮肤红斑）加总分≥10分的免疫学指标（如抗核抗体阳性、补体水平降低）。确诊需结合临床表现与实验室检查（来源：Arthritis & Rheumatology期刊）。
治疗方案根据疾病活动度分级：
该疾病的5年生存率已超过95%，但长期管理需关注药物副作用和并发症预防。患者应定期监测尿蛋白、补体水平和抗dsDNA抗体滴度，以评估疾病活动度（来源：《新英格兰医学杂志》综述）。
Systemic lupus erythematosus（SLE）是一种累及多器官的慢性自身免疫性疾病，其名称来源于拉丁语：
疾病本质
属于自身免疫性疾病，因免疫系统异常攻击自身组织，导致多器官炎症和损伤。常见于15-45岁育龄期女性（男女比例约1:9）。
典型症状
病因与诱因
尚未完全明确，与遗传易感性、雌激素水平升高、病毒感染（如EB病毒）、紫外线照射等因素相关。
治疗与管理
需长期规范治疗，常用药物包括羟氯喹（抗疟药）、糖皮质激素（如泼尼松）、免疫抑制剂（如环磷酰胺）等，目标是控制炎症、减少器官损伤。
英文例句（来自权威文献）：
"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the production of autoantibodies."
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