鹽酸普魯卡因
Objective To establish a HPLC method for the content determination of procaine hydrochloride in Gentamicin Procaine Vitamin B12 Granules.
目的建立測定慶大黴素普魯卡因維B12顆粒中鹽酸普魯卡因含量的方法。
Contents of procaine hydrochloride and its degradation product p-amino benzoic acid were determined in procaine hydrochloride injection by RP-HPLC.
用高效液相色譜法測定鹽酸普魯卡因注射液中鹽酸普魯卡因和其降解産物*********苯甲酸的含量。
CONCLUSION Bacterial endotoxin test can be used in place of the rabbit pyrogen test for monitoring bacterial endotoxin of procaine hydrochloride for injection.
結果注射用鹽酸普魯卡因對鲎試劑的凝聚反應無幹擾作用。
OBJECTIVE To investigate the effect of butyl rubber stopper on the stability of procaine hydrochloride injection.
目的：考察注射用鹽酸普魯卡因的細菌内毒素檢查的方法。
OBJECTIVE To establish a method of bacterial endotoxin test for procaine hydrochloride injection.
目的建立鹽酸普魯卡因注射液的細菌内毒素檢查方法。
OBJECTIVE: To examine the method for testing Bacterial Endotoxin in procaine hydrochloride for injection.
目的：考察注射用鹽酸普魯卡因的細菌内毒素檢查的方法。
OBJECTIVE To establish a method for quantitative analysis of procaine hydrochloride and its decomposed product p -aminobenzoic acid(PABA) simultaneously.
目的建立雙相紫外分光光度法同時定量測定鹽酸普魯卡因及其分解産物*********苯甲酸（PABA）。
A standard adding method was used for the determination of procaine hydrochloride injection.
采用标準加入法，對針劑中的普魯卡因進行測定，得到滿意結果。
Kinetic turbidimetric limulus test for determination of bacterial endotoxin in procaine hydrochloride injection and the interferential factors was investigated.
用動态濁度法測定普魯卡因注射液中細菌内毒素含量及影響因素。
The first derivative ratio spectrometry was used for the determination of the procaine hydrochloride injection.
鹽酸普魯卡因注射液是臨床常用的局麻藥。
Conclusion The method is convenient, rapid and accurate, which may be used to assay PABA in procaine hydrochloride injection.
結論：本測定方法簡便快速，結果準确，可用于該制劑有關物質檢查。
Why is the limit of 4-aminobenzoic acid tested for Procaine Hydrochloride?
鹽酸普魯卡因注射液中為什麼要檢查*********苯甲酸?。
Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection.
目的考察溫度和濕度對普魯卡因注射液的穩定性影響。
RESULTS The drug effect of the compound injection was better than that of procaine or lidocaine hydrochloride injection in same concentration.
結果：複方鹽酸普魯卡因注射液藥效均強于相同濃度的鹽酸普魯卡因與鹽酸利多卡因。
Aim To study the influence of light and heat on the stability of procaine hydrochloride injection.
目的研究鹽酸普魯卡因注射液在光和熱同時作用下的穩定性。
OBJECTIVE:To investigate the effects of current intensity and drug concentration on iontophoresis of procaine hydrochloride.
目的：考察鹽酸普魯卡因的離子導入與電流強度、藥物濃度的關系。
OBJECTIVE To examine the method for test bacterial endotoxin in procaine hydrochloride for injection (PHI).
目的考察注射用鹽酸普魯卡因的細菌内毒素檢查的方法。
Compound anisodine injection is a compound preparation made from hydrobromide anisodine and procaine hydrochloride.
複方樟柳堿注射液為*********樟柳堿和鹽酸普魯卡因複方制劑。
Conclusion: This method can not only keep between 95% and 105% of the mark amount in the content of procaine hydrochloride, but also reach the criteria of sterilization.
結論：本方法既可使鹽酸普魯卡因含量保持在标示量的95%-105%範圍，又達到了滅菌要求。
OBJECTIVE To prepare compound injection of procaine hydrochloride in order to overcome the short comings of single injection of procaine hydrochloride.
目的：研制一種複方鹽酸普魯卡因注射液以解決單方普魯卡因注射液存在的缺點和不足。
Objective: to establish a fast identification method of procaine hydrochloride injection according to the need of marketplace.
目的：為適應市場需求，建立鹽酸普魯卡因注射液的快速鑒别方法。
Therefore, its local anesthetic action is similar to that produced by 1 % procaine hydrochloride, but it produces a more weaker and shorter lasting anesthesia than procaine.
蛇床子提取液的局麻作用相似于1%鹽酸普魯卡因，唯作用強度較弱、持續時間較短。
Methods The enhancing rate (ER) of procaine hydrochloride with different voltage through rat skin were determined respectively using vaila-chien two-chamber diffusion cells.
方法以鹽酸普魯卡因為模型藥物，采用去毛大鼠腹部皮膚和雙室擴散池，分别測定不同電壓下的滲透速率（ER）。
OBJECTIVE:To determine the content of procaine hydrochloride in Procaine hydrochloride injection.
目的：測定複方普魯卡因注射液中普魯卡因的含量。
OBJECTIVE To establish a bacterial endotoxin test for procaine hydrochloride injection.
目的建立鹽酸普魯卡因注射液的細菌内毒素檢查法。
What are the principles of the identification of Procaine Hydrochloride.
鹽酸普魯卡因的鑒别原理是什麼？
Objective: To study the preparing technology of compound gentamycin sulface sugar-free and procaine hydrochloride granules.
前言：目的：研制無糖型複方慶大黴素普魯卡因顆粒。
普魯卡因鹽酸鹽（procaine hydrochloride）是一種局部麻醉藥物，其化學名稱為2-二乙氨基乙基-4-氨基苯甲酸酯鹽酸鹽。該化合物由德國化學家阿爾弗雷德·艾因霍恩于1905年首次合成，是第一種人工合成的非成瘾性局麻藥，取代了此前具有毒性的可卡因類麻醉劑。
從化學結構來看，普魯卡因鹽酸鹽由苯環、酯鍵和氨基三部分構成，分子式為C₁₃H₂₀N₂O₂·HCl，相對分子質量為272.77。其水溶液呈酸性（pH 3.0-6.0），在體内通過酯酶水解為對氨基苯甲酸和二乙氨基乙醇代謝。藥理學研究表明，該藥物通過可逆性阻斷神經細胞膜鈉離子通道，抑制動作電位傳導，從而産生麻醉效果，持續時間約30-60分鐘。
臨床應用方面，普魯卡因鹽酸鹽主要用于浸潤麻醉、神經阻滞麻醉和蛛網膜下腔麻醉。根據《中華人民共和國藥典》（2020年版）收錄，其注射劑常用濃度為0.25%-2%，極量單次不超過1g。世界衛生組織基本藥物标準清單将其列為重要的基礎醫療藥物，特别適用于資源有限地區的醫療場景。
安全性數據表明，普魯卡因鹽酸鹽的不良反應發生率約為6%-8%，主要包括過敏反應、低血壓和中樞神經系統興奮症狀。美國食品藥品監督管理局（FDA）要求其注射液必須标注「含對氨基苯甲酸酯結構」的警示信息，因該結構可能引發交叉過敏反應。近年研究還發現該藥物具有調節細胞膜鈣離子通道的作用，在神經病理性疼痛治療領域展現出新的應用潛力。
Procaine hydrochloride（鹽酸普魯卡因）是一種局部麻醉藥物，具體解釋如下：
如需更詳細藥品信息（如劑量、劑型），可參考藥典或專業醫學資料。
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