盐酸普鲁卡因
Objective To establish a HPLC method for the content determination of procaine hydrochloride in Gentamicin Procaine Vitamin B12 Granules.
目的建立测定庆大霉素普鲁卡因维B12颗粒中盐酸普鲁卡因含量的方法。
Contents of procaine hydrochloride and its degradation product p-amino benzoic acid were determined in procaine hydrochloride injection by RP-HPLC.
用高效液相色谱法测定盐酸普鲁卡因注射液中盐酸普鲁卡因和其降解产物*********苯甲酸的含量。
CONCLUSION Bacterial endotoxin test can be used in place of the rabbit pyrogen test for monitoring bacterial endotoxin of procaine hydrochloride for injection.
结果注射用盐酸普鲁卡因对鲎试剂的凝聚反应无干扰作用。
OBJECTIVE To investigate the effect of butyl rubber stopper on the stability of procaine hydrochloride injection.
目的：考察注射用盐酸普鲁卡因的细菌内毒素检查的方法。
OBJECTIVE To establish a method of bacterial endotoxin test for procaine hydrochloride injection.
目的建立盐酸普鲁卡因注射液的细菌内毒素检查方法。
OBJECTIVE: To examine the method for testing Bacterial Endotoxin in procaine hydrochloride for injection.
目的：考察注射用盐酸普鲁卡因的细菌内毒素检查的方法。
OBJECTIVE To establish a method for quantitative analysis of procaine hydrochloride and its decomposed product p -aminobenzoic acid(PABA) simultaneously.
目的建立双相紫外分光光度法同时定量测定盐酸普鲁卡因及其分解产物*********苯甲酸（PABA）。
A standard adding method was used for the determination of procaine hydrochloride injection.
采用标准加入法，对针剂中的普鲁卡因进行测定，得到满意结果。
Kinetic turbidimetric limulus test for determination of bacterial endotoxin in procaine hydrochloride injection and the interferential factors was investigated.
用动态浊度法测定普鲁卡因注射液中细菌内毒素含量及影响因素。
The first derivative ratio spectrometry was used for the determination of the procaine hydrochloride injection.
盐酸普鲁卡因注射液是临床常用的局麻药。
Conclusion The method is convenient, rapid and accurate, which may be used to assay PABA in procaine hydrochloride injection.
结论：本测定方法简便快速，结果准确，可用于该制剂有关物质检查。
Why is the limit of 4-aminobenzoic acid tested for Procaine Hydrochloride?
盐酸普鲁卡因注射液中为什么要检查*********苯甲酸?。
Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection.
目的考察温度和湿度对普鲁卡因注射液的稳定性影响。
RESULTS The drug effect of the compound injection was better than that of procaine or lidocaine hydrochloride injection in same concentration.
结果：复方盐酸普鲁卡因注射液药效均强于相同浓度的盐酸普鲁卡因与盐酸利多卡因。
Aim To study the influence of light and heat on the stability of procaine hydrochloride injection.
目的研究盐酸普鲁卡因注射液在光和热同时作用下的稳定性。
OBJECTIVE:To investigate the effects of current intensity and drug concentration on iontophoresis of procaine hydrochloride.
目的：考察盐酸普鲁卡因的离子导入与电流强度、药物浓度的关系。
OBJECTIVE To examine the method for test bacterial endotoxin in procaine hydrochloride for injection (PHI).
目的考察注射用盐酸普鲁卡因的细菌内毒素检查的方法。
Compound anisodine injection is a compound preparation made from hydrobromide anisodine and procaine hydrochloride.
复方樟柳碱注射液为*********樟柳碱和盐酸普鲁卡因复方制剂。
Conclusion: This method can not only keep between 95% and 105% of the mark amount in the content of procaine hydrochloride, but also reach the criteria of sterilization.
结论：本方法既可使盐酸普鲁卡因含量保持在标示量的95%-105%范围，又达到了灭菌要求。
OBJECTIVE To prepare compound injection of procaine hydrochloride in order to overcome the short comings of single injection of procaine hydrochloride.
目的：研制一种复方盐酸普鲁卡因注射液以解决单方普鲁卡因注射液存在的缺点和不足。
Objective: to establish a fast identification method of procaine hydrochloride injection according to the need of marketplace.
目的：为适应市场需求，建立盐酸普鲁卡因注射液的快速鉴别方法。
Therefore, its local anesthetic action is similar to that produced by 1 % procaine hydrochloride, but it produces a more weaker and shorter lasting anesthesia than procaine.
蛇床子提取液的局麻作用相似于1%盐酸普鲁卡因，唯作用强度较弱、持续时间较短。
Methods The enhancing rate (ER) of procaine hydrochloride with different voltage through rat skin were determined respectively using vaila-chien two-chamber diffusion cells.
方法以盐酸普鲁卡因为模型药物，采用去毛大鼠腹部皮肤和双室扩散池，分别测定不同电压下的渗透速率（ER）。
OBJECTIVE:To determine the content of procaine hydrochloride in Procaine hydrochloride injection.
目的：测定复方普鲁卡因注射液中普鲁卡因的含量。
OBJECTIVE To establish a bacterial endotoxin test for procaine hydrochloride injection.
目的建立盐酸普鲁卡因注射液的细菌内毒素检查法。
What are the principles of the identification of Procaine Hydrochloride.
盐酸普鲁卡因的鉴别原理是什么？
Objective: To study the preparing technology of compound gentamycin sulface sugar-free and procaine hydrochloride granules.
前言：目的：研制无糖型复方庆大霉素普鲁卡因颗粒。
普鲁卡因盐酸盐（procaine hydrochloride）是一种局部麻醉药物，其化学名称为2-二乙氨基乙基-4-氨基苯甲酸酯盐酸盐。该化合物由德国化学家阿尔弗雷德·艾因霍恩于1905年首次合成，是第一种人工合成的非成瘾性局麻药，取代了此前具有毒性的可卡因类麻醉剂。
从化学结构来看，普鲁卡因盐酸盐由苯环、酯键和氨基三部分构成，分子式为C₁₃H₂₀N₂O₂·HCl，相对分子质量为272.77。其水溶液呈酸性（pH 3.0-6.0），在体内通过酯酶水解为对氨基苯甲酸和二乙氨基乙醇代谢。药理学研究表明，该药物通过可逆性阻断神经细胞膜钠离子通道，抑制动作电位传导，从而产生麻醉效果，持续时间约30-60分钟。
临床应用方面，普鲁卡因盐酸盐主要用于浸润麻醉、神经阻滞麻醉和蛛网膜下腔麻醉。根据《中华人民共和国药典》（2020年版）收录，其注射剂常用浓度为0.25%-2%，极量单次不超过1g。世界卫生组织基本药物标准清单将其列为重要的基础医疗药物，特别适用于资源有限地区的医疗场景。
安全性数据表明，普鲁卡因盐酸盐的不良反应发生率约为6%-8%，主要包括过敏反应、低血压和中枢神经系统兴奋症状。美国食品药品监督管理局（FDA）要求其注射液必须标注「含对氨基苯甲酸酯结构」的警示信息，因该结构可能引发交叉过敏反应。近年研究还发现该药物具有调节细胞膜钙离子通道的作用，在神经病理性疼痛治疗领域展现出新的应用潜力。
Procaine hydrochloride（盐酸普鲁卡因）是一种局部麻醉药物，具体解释如下：
如需更详细药品信息（如剂量、剂型），可参考药典或专业医学资料。
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