
n. 环己亚硝脲(抗癌药);罗氮芥
Lomustine liposomes were prepared by the reversed-phase evaporation method.
采用逆相蒸发法制备洛莫司汀脂质体。
OBJECTIVE To prepare Lomustine thermo-sensitive liposomes (CCNU-TSL) and investigate the anti-tumor activity in vitro.
目的制备洛莫司汀热敏脂质体并考察其体外抗肿瘤活性。
CONCLUSION the drug release percents and the tumor control rates of CCNU-TSL are improved significantly compared with lomustine solution in vitro.
结论洛莫司汀热敏脂质体在相变温度时,体外释药明显增加,体外抑瘤效果明显提高。
Chemotherapy was given according to the protocol which consisted of lomustine, cisplatinum and vincristine after radiotherapy, but the patients were not given intrathecal chemotherapy.
所有患儿于放疗后接受长春新碱、环己亚硝脲、顺铂方案化疗,所有患者均未行鞘内化疗。
Lomustine(洛莫司汀)是一种重要的烷化剂类化疗药物,主要用于治疗某些类型的脑肿瘤和淋巴瘤。以下是其详细解释:
Lomustine属于亚硝基脲类烷化剂,可通过血脑屏障进入中枢神经系统。其作用机制是通过烷基化DNA双链,导致DNA交联和断裂,干扰肿瘤细胞DNA复制与修复功能,最终诱导癌细胞凋亡。
作为复发性高级别胶质瘤(如胶质母细胞瘤)的二线治疗药物,常与放疗联用。美国国家综合癌症网络(NCCN)指南推荐其用于间变性星形细胞瘤的辅助治疗。
适用于对其他化疗方案耐药或复发的霍奇金淋巴瘤患者,通常作为联合化疗方案(如BEACOPP)的组成部分。
小细胞肺癌、黑色素瘤的姑息治疗(需根据个体化方案评估)。
注:以上链接为真实权威来源,临床用药请以最新版药品说明书和诊疗规范为准。
Lomustine(中文名:洛莫司汀)是一种烷基化类抗肿瘤药物,主要用于治疗多种恶性肿瘤。以下是综合信息的详细解释:
如需更完整的药物信息(如具体剂量调整或临床试验数据),可参考药典或专业肿瘤治疗指南。
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