慢性骨髓白血病；慢性粒细胞白血病
Front-Line Therapy With Second-Generation Tyrosine Kinase Inhibitors in Patients With Early Chronic Phase Chronic Myeloid Leukemia: What Is the Optimal Response?
使用二代酪氨酸激酶抑制剂作为一线疗法治疗早期慢性期慢性粒细胞白血病患者：什么是最佳的反应？
Recently, elevated IL-18 levels were found in serum from some leukemia patients, especially those with acute lymphocytic leukemia (ALL) and chronic myeloid leukemia (CML).
近来，研究发现急性淋巴细胞白血病（ALL）和慢性粒细胞白血病（CML）患者血清中IL-18水平高于正常人。
Objective To analyze the frequency and clinical significance of ABL tyrosine kinase point mutations in chronic myeloid leukemia (CML) patients receiving imatinib treatment.
目的探讨伊马替尼治疗慢性粒细胞白血病（CML）患者ABL酪氨酸激酶区点突变的发生情况及临床意义。
Objective To study the gene expression profile of chronic myeloid leukemia(CML) in chronic and blast phases for providing information about the potential mechanisms of blastic crisis.
目的研究慢性粒细胞白血病（CML）不同临床阶段的基因表达差异，为阐明CML演变的可能机制提供依据。
Eight samples of bone marrow coming from patients affected by acute myeloid leukemia (AML) and nine samples from patients suffered from chronic myeloid leukemia(CML) were stu***d by FTIR spectroscopy.
研究了急性粒细胞白血病（ AML）和慢性粒细胞白血病（ CML）患者的骨髓淋巴细胞、粒细胞和红细胞的傅立叶红外光谱（ FTIR） 。
Objective To evaluate the prognostic factors of chronic myeloid leukemia(CML).
目的研究影响慢性粒细胞白血病（CML）生存的预后因素。
Philadelphia chromosome formed may result in the generation of the fusion protein BCR ABL, a constitutively activated tyrosine ki nas e which then causes chronic myeloid leukemia (CML).
慢性粒细胞白血病（CML）患者体内有异常染色体形成并产生BCRABL融合蛋白，该融合蛋白能激活酪氨酸激酶，刺激细胞过度增生导致慢性粒细胞白血病的发生。
Objective: To induce and differentiate into dendritic cells from leukemic cells of patients with chronic myeloid leukemia.
目的：将慢性髓性白血病患者的白血病细胞体外诱导分化成为树突状细胞。
A writer and translator living in Manhattan, she was suffering from chronic myeloid leukemia, an especially deadly form of blood cancer.
她是一位作家和翻译家，住在曼哈顿，当时正患慢性髓细胞样白血病，一种特殊的致死性血癌。
Objective:Observation of bone marrow smears of typical chronic myeloid leukemia to investigate the Possibility of morphological classification of the disease.
目的：观察典型慢性髓系白血病骨髓涂片，探讨用常规血细胞形态学方法分型的可能性。
Objective To detect the ABL point mutations in chronic myeloid leukemia(CML)patients treated with imatinib by denaturing high-performance liquid chromatography(DHPLC).
目的应用变性高效液相色谱（DHPLC）检测伊马替尼治疗后慢性髓性白血病（CML）患者ABL激酶区点突变。
Objective To explore the value of interphase fluorescence in situ hybridization(I-FISH) on the detection of trisomy 8 in chronic myeloid leukemia(CML) and the progression of CML.
目的探讨间期荧光原位杂交（I-FISH）技术检测慢性髓系白血病（CML）8号染色体三体（8三体）异常的价值及其对CML演进监测的意义。
Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?
选择最佳的二线酪氨酸激酶抑制剂治疗伊马替尼治疗失败的慢性粒细胞白细胞患者：BCR-ABL突变状态是否真的重要？
Objective: TO observe the effect of Zubianling capsule in treating chronic myeloid leukemia.
目的观察阻变灵胶囊治疗慢性粒细胞白血病的疗效。
Recent research shows that, HHT can be used for the chronic myeloid leukemia patients after the failure of interferon therapy or imatinib-resistant.
近期研究表明，HHT还可用于干扰素治疗失败和伊马替尼耐药的慢性粒细胞白血病的治疗。
Imatinib is currently the most popular therapy for chronic myeloid leukemia (CML).
伊马替尼是目前治疗慢性髓细胞白血病的最普遍药物。
Objective To study the changes of cytogenetics and molecular genetics in chronic myeloid leukemia blast crisis(CML-BC).
目的研究慢性髓细胞白血病急变期（CML-BC）细胞遗传学及分子遗传学改变。
Objective To study the vascular endothelium growth factor (VEGF) antisense oligonucleotide (ASON) Cinobufotalin in enhancing apoptosis induced by human chronic myeloid leukemia K562 cell line.
目的研究VEGF反义核酸（ASON）增强华蟾素对人慢性粒细胞白血病K562细胞株诱导凋亡效应。
All-time NBA top scorer Kareem Abdul-Jabbar has been diagnosed with chronic myeloid leukemia, he said during an interview with the Los Angeles Times.
NBA史上得分王卡里姆·阿卜杜尔-贾巴尔日前在接受《洛杉矶时报》的采访时披露，自己被确诊患上慢性粒细胞性白血病。
Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients?
用伊马替尼治疗的慢性粒细胞白血病（CML）患者血浆脂联素浓度显著升高：这是改善2型糖尿病CML患者胰岛素敏感性的一种机制？
Objective To explore the expression of PTTG gene of chronic myeloid leukemia(CML)in different phases for providing information about the potential mechanisms of CML.
目的研究垂体瘤转化基因（PTTG）在慢性粒性细胞白血病（CML）患者中不同临床阶段的基因表达，为阐明CML演变的可能机制提供依据。
Conclusion OD-PTD fusion protein can significantly inhibit the proliferation of K562 cells, which provides an experimental basis for new therapy of chronic myeloid leukemia.
结论OD-PTD融合蛋白对K562细胞有明显的抑制作用，为进一步探讨慢性粒细胞白血病新的治疗手段提供了实验依据。
The WT1 expression level of chronic myeloid leukemia(CML) in blast crisis was higher than that of CML in chronic phase.
慢性髓性白血病（CML）急变期患者WT1基因表达水平显著高于慢性期。
Chronic myeloid leukemia (CML) is a clonal hematologic malignancy that arise in the stem cell compartment .
研究背景慢性髄细胞白血病（CML）是一种起源于多能造血干细胞的克隆性恶性血液病。
For example, patients with chronic myeloid leukemia, a blood cancer, nearly always have swapped pieces of chromosomes 9 and 22 in their cancer cells.
例如，慢性粒细胞白血病（chronic myeloid leukemia）是一种血细胞癌症，其癌细胞中总会发生9号染色体与22号染色体之间部分的交换。
There is another convincing case related to chronic myeloid leukemia.
另一个令人信服的案例就是慢性骨髓性白血病。
慢性粒细胞白血病（Chronic Myeloid Leukemia, CML）是一种起源于骨髓造血干细胞的恶性血液肿瘤，其特征是髓系细胞（尤其是粒细胞）不受控制地增殖。以下是其核心特征的详细解释：
病理机制与遗传学基础
95%以上的CML患者存在费城染色体（Philadelphia chromosome），这是由9号染色体与22号染色体长臂易位（t(9;22)(q34;q11)）形成的异常染色体。该易位导致BCR基因与ABL1基因融合，产生BCR-ABL1融合基因。此基因编码一种组成型激活的酪氨酸激酶蛋白，持续刺激细胞增殖、抑制细胞凋亡，最终导致白血病发生。
疾病分期与临床表现
CML分为三个临床阶段：
诊断方法
确诊需结合：
靶向治疗与预后
酪氨酸激酶抑制剂（Tyrosine Kinase Inhibitors, TKIs）（如伊马替尼、尼洛替尼、达沙替尼）是标准一线治疗，通过抑制BCR-ABL1蛋白活性控制疾病。多数慢性期患者经TKI治疗可获得长期生存，部分可达深度分子学缓解（BCR-ABL1转录本不可测）。耐药或进展至晚期患者可能需干细胞移植或新型靶向药治疗。
权威参考资料来源：
慢性髓系白血病（Chronic Myeloid Leukemia, CML）是一种造血干细胞恶性克隆性疾病，属于慢性白血病的一种。以下是详细解释：
CML是一种以髓系细胞异常增殖为主的血液系统恶性肿瘤，主要累及粒细胞系。其核心特征是存在Ph染色体（费城染色体）或BCR-ABL融合基因，这是诊断的必要条件。患者外周血中粒细胞显著增多，并伴随脾脏肿大。
CML起源于多能造血干细胞的基因突变，95%以上病例由t(9;22)(q34;q11)染色体易位导致，形成BCR-ABL融合基因。该基因编码的异常蛋白具有持续酪氨酸激酶活性，促使细胞不受控增殖。
CML也被称为慢性粒细胞白血病（Chronic Granulocytic Leukemia），英文缩写均为CML。其属于慢性白血病范畴，与急性白血病相比进展较缓慢。
如需进一步了解治疗或流行病学数据，可参考权威医学文献或临床指南。
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