[遺] 染色體畸變
Monitoring chromosome aberration and microkernel used little blood cultivate method.
微量全血培養法檢測染色體畸變及微核。
Methods The micronucleus test of bone marrow cells, chromosome aberration test of bone marrow cells, sperm shape abnormality test in mice were carried out and the results were analyzed.
方法采用小鼠骨髓細胞微核試驗、小鼠骨髓細胞染色體畸變試驗、小鼠精子畸形試驗進行觀察。
Objective:To study the relationship between the chromosome aberration and the male infertility.
目的研究男性染色體異常與男性不育之間的關系。
Objective To study the sense of increasing frequency of chromosome aberration for health inspection in X-ray workers.
目的探讨染色體型畸變率增加在射線工作者健康監護中應用的意義。
Objective: To investigate the relationships between the recrudescence abortion and chromosome aberration.
目的：讨論患者夫婦外周血染色體異常與反複流産的關系。
Conclusion Long—term low-dose radiation exposure is the risk factor of the chromosome aberration. The chromosome aberration increase with the accumulate radiation doses increasing in five years.
結論長期職業性小劑量外照射是染色體畸變的危險因素，并且有隨着近五年累積受照劑量的增加而增加。
Results The chromosome aberration in all the group of treated by low dose MMC was lower than that in the 2Gy X-ray group.
結果所有低劑量MMC處理組小鼠骨髓細胞染色體畸變率均低于單純大劑量照射組。
The types of the structural chromosome aberration mainly were chromatid gap, chromatid break and deletion.
結構畸變類型主要是單體裂隙、單體斷裂和缺失。
DON was mutagenic in many mammalian cells in vitro using chromosome aberration.
體外試驗顯示，DON可引起染色體畸變。
The karyotype of their chromosomes were normal (46XY or 46XX), no chromosome aberration, chromosome loss and polyploid.
所有患者染色體核型均正常，未見染色體核型缺失及多倍體，均為46XY或46XX型。
Conclusions Rises of chromosome aberration and micronuclei frequency are caused by lowdose and long…
結論長期小劑量外照射可引起染色體畸變和微核檢出率升高。
The chromosome aberration frequency was increased when lymphocytes were cultured in medium deficient in folate and thymidine (MEM-FA).
實驗結果表明，MEM-FA中培養的細胞染色體自發畸變率顯著高于完全培養基（MEM）。
Conclusions:Chromosome aberration is important causes of lower intelligence and physically maldeveioped.
結論：結果表明染色體異常是導緻智力低下和發育異常的重要原因。
The effect of arginine esterase (an effective component of ahylysantinfarctase) on CHL cell growth inhibition and chromosome aberration in vitro was stu***d.
試驗結果表明，精氨酸酯酶在上述濃度對CHL細胞的增殖沒有抑制作用，對CHL細胞的染色體結構也沒有影響。
Moreover, the frequency of chromosome aberration increased with the increasing of treatment duration.
而且隨着處理時間的增加，染色體畸變率也在增加。
The rate of cells with chromosome aberration was increased with protons energy and dose added.
隨着質子能量和劑量的提高，染色體畸變細胞率呈增加趨勢。
Objective To explore the correlation of chromosome aberration and the hemogram variation in X-ray workers and provide the mechanism index for radiation damage.
目的探讨X射線工作人員染色體畸變與血象變化的關系，為輻射損傷機制提供線索。
Methods The micronucleus assay in mice marrow PCE and chromosome aberration assay in mice marrow cells are used.
方法采用小鼠骨髓細胞微核試驗和小鼠骨髓細胞染色體畸變試驗。
Methods: The mice's sternum marrow cell chromosome aberration and micronucleus rate were adopted as observation indexes to evaluate their preventive and curative effects.
方法：将小鼠骨髓細胞染色體畸變率和微核率作為觀察指标，來評價沙棘等蔬菜水果的預防治療效果。
There is correlation between chromosome aberration and the abnormal WBC.
染色體畸變與白細胞異常有關聯。
It has been proved that EDTA was a very effective sensitizing agent and increased the chromosome aberration evidently.
已經證實，EDTA是一種非常有效的輻射敏化劑，能顯著地提高染色體畸變率。
|chromosomal aberration;[遺]染色體畸變
染色體畸變（chromosome aberration）是指染色體在結構或數量上發生的異常改變，可能由遺傳因素、環境誘變劑或細胞分裂錯誤導緻。這類異常可引發發育障礙、先天性疾病或腫瘤等健康問題，是遺傳學和醫學研究的重要領域。
染色體結構畸變包括缺失（deletion）、重複（duplication）、倒位（inversion）和易位（translocation）。例如慢性粒細胞白血病中常見的費城染色體，即9號與22號染色體發生相互易位形成融合基因BCR-ABL1，這一現象被美國國家癌症研究所（來源：National Cancer Institute）列為血液系統惡性腫瘤的經典遺傳學改變。
數目畸變分為整倍體變異（如三倍體）和非整倍體變異（如唐氏綜合征的21三體）。人類基因組計劃（來源：Human Genome Project）數據顯示，約50%的早期流産胚胎存在染色體數目異常，其中最常見的為16三體。
核型分析和熒光原位雜交（FISH）是主要檢測手段。世界衛生組織（來源：World Health Organization）指出，染色體異常導緻全球約6%的出生缺陷，其中數目異常占活産兒的0.3%。例如克氏綜合征（47,XXY）作為性染色體非整倍體典型病例，可通過産前篩查進行早期診斷。
染色體畸變（chromosome aberration）是指細胞中染色體數目或結構發生異常改變的現象，可能由遺傳因素或環境誘變因素（如化學物質、輻射等）引起。以下是詳細解釋：
一、核心定義 指體細胞或生殖細胞内染色體數目增減或結構異常，包括數量畸變（如多倍體、非整倍體）和結構畸變（如缺失、重複、倒位、易位）。
二、主要分類
數目畸變
結構畸變
三、發生原因
四、健康影響 可能導緻先天畸形（如特納綜合征）、智力障礙、流産或不孕，也與白血病等癌症相關。實驗顯示砷酸鹽等化學物質可誘發小鼠骨髓細胞染色體畸變。
注：染色體檢查是産前診斷和腫瘤研究的重要手段，具體案例可參考遺傳學臨床研究文獻。
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