[遗] 染色体畸变
Monitoring chromosome aberration and microkernel used little blood cultivate method.
微量全血培养法检测染色体畸变及微核。
Methods The micronucleus test of bone marrow cells, chromosome aberration test of bone marrow cells, sperm shape abnormality test in mice were carried out and the results were analyzed.
方法采用小鼠骨髓细胞微核试验、小鼠骨髓细胞染色体畸变试验、小鼠精子畸形试验进行观察。
Objective:To study the relationship between the chromosome aberration and the male infertility.
目的研究男性染色体异常与男性不育之间的关系。
Objective To study the sense of increasing frequency of chromosome aberration for health inspection in X-ray workers.
目的探讨染色体型畸变率增加在射线工作者健康监护中应用的意义。
Objective: To investigate the relationships between the recrudescence abortion and chromosome aberration.
目的：讨论患者夫妇外周血染色体异常与反复流产的关系。
Conclusion Long—term low-dose radiation exposure is the risk factor of the chromosome aberration. The chromosome aberration increase with the accumulate radiation doses increasing in five years.
结论长期职业性小剂量外照射是染色体畸变的危险因素，并且有随着近五年累积受照剂量的增加而增加。
Results The chromosome aberration in all the group of treated by low dose MMC was lower than that in the 2Gy X-ray group.
结果所有低剂量MMC处理组小鼠骨髓细胞染色体畸变率均低于单纯大剂量照射组。
The types of the structural chromosome aberration mainly were chromatid gap, chromatid break and deletion.
结构畸变类型主要是单体裂隙、单体断裂和缺失。
DON was mutagenic in many mammalian cells in vitro using chromosome aberration.
体外试验显示，DON可引起染色体畸变。
The karyotype of their chromosomes were normal (46XY or 46XX), no chromosome aberration, chromosome loss and polyploid.
所有患者染色体核型均正常，未见染色体核型缺失及多倍体，均为46XY或46XX型。
Conclusions Rises of chromosome aberration and micronuclei frequency are caused by lowdose and long…
结论长期小剂量外照射可引起染色体畸变和微核检出率升高。
The chromosome aberration frequency was increased when lymphocytes were cultured in medium deficient in folate and thymidine (MEM-FA).
实验结果表明，MEM-FA中培养的细胞染色体自发畸变率显著高于完全培养基（MEM）。
Conclusions:Chromosome aberration is important causes of lower intelligence and physically maldeveioped.
结论：结果表明染色体异常是导致智力低下和发育异常的重要原因。
The effect of arginine esterase (an effective component of ahylysantinfarctase) on CHL cell growth inhibition and chromosome aberration in vitro was stu***d.
试验结果表明，精氨酸酯酶在上述浓度对CHL细胞的增殖没有抑制作用，对CHL细胞的染色体结构也没有影响。
Moreover, the frequency of chromosome aberration increased with the increasing of treatment duration.
而且随着处理时间的增加，染色体畸变率也在增加。
The rate of cells with chromosome aberration was increased with protons energy and dose added.
随着质子能量和剂量的提高，染色体畸变细胞率呈增加趋势。
Objective To explore the correlation of chromosome aberration and the hemogram variation in X-ray workers and provide the mechanism index for radiation damage.
目的探讨X射线工作人员染色体畸变与血象变化的关系，为辐射损伤机制提供线索。
Methods The micronucleus assay in mice marrow PCE and chromosome aberration assay in mice marrow cells are used.
方法采用小鼠骨髓细胞微核试验和小鼠骨髓细胞染色体畸变试验。
Methods: The mice's sternum marrow cell chromosome aberration and micronucleus rate were adopted as observation indexes to evaluate their preventive and curative effects.
方法：将小鼠骨髓细胞染色体畸变率和微核率作为观察指标，来评价沙棘等蔬菜水果的预防治疗效果。
There is correlation between chromosome aberration and the abnormal WBC.
染色体畸变与白细胞异常有关联。
It has been proved that EDTA was a very effective sensitizing agent and increased the chromosome aberration evidently.
已经证实，EDTA是一种非常有效的辐射敏化剂，能显著地提高染色体畸变率。
|chromosomal aberration;[遗]染色体畸变
染色体畸变（chromosome aberration）是指染色体在结构或数量上发生的异常改变，可能由遗传因素、环境诱变剂或细胞分裂错误导致。这类异常可引发发育障碍、先天性疾病或肿瘤等健康问题，是遗传学和医学研究的重要领域。
染色体结构畸变包括缺失（deletion）、重复（duplication）、倒位（inversion）和易位（translocation）。例如慢性粒细胞白血病中常见的费城染色体，即9号与22号染色体发生相互易位形成融合基因BCR-ABL1，这一现象被美国国家癌症研究所（来源：National Cancer Institute）列为血液系统恶性肿瘤的经典遗传学改变。
数目畸变分为整倍体变异（如三倍体）和非整倍体变异（如唐氏综合征的21三体）。人类基因组计划（来源：Human Genome Project）数据显示，约50%的早期流产胚胎存在染色体数目异常，其中最常见的为16三体。
核型分析和荧光原位杂交（FISH）是主要检测手段。世界卫生组织（来源：World Health Organization）指出，染色体异常导致全球约6%的出生缺陷，其中数目异常占活产儿的0.3%。例如克氏综合征（47,XXY）作为性染色体非整倍体典型病例，可通过产前筛查进行早期诊断。
染色体畸变（chromosome aberration）是指细胞中染色体数目或结构发生异常改变的现象，可能由遗传因素或环境诱变因素（如化学物质、辐射等）引起。以下是详细解释：
一、核心定义 指体细胞或生殖细胞内染色体数目增减或结构异常，包括数量畸变（如多倍体、非整倍体）和结构畸变（如缺失、重复、倒位、易位）。
二、主要分类
数目畸变
结构畸变
三、发生原因
四、健康影响 可能导致先天畸形（如特纳综合征）、智力障碍、流产或不孕，也与白血病等癌症相关。实验显示砷酸盐等化学物质可诱发小鼠骨髓细胞染色体畸变。
注：染色体检查是产前诊断和肿瘤研究的重要手段，具体案例可参考遗传学临床研究文献。
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