
[免疫] 中和抗體
Also, neutralizing antibody of paired sera were detected.
此外,還測定患兒雙份血中病毒的中和抗體增長。
In 11 patients of PM/DM with muscular pain , the positive rates of enterovirus RNA were 72.73% , higher than that of neutralizing antibody test (18.18% ).
在有肌肉酸痛症狀的患者(11例)中,腸道病毒RNA的陽性率為72.73%,明顯高于中和抗體的陽性率(18.18% );
Aim To investigate the effects of grown releasing hormone-pseudomonas aeruginosa exotoxin 38(GP38) neutralizing antibody on drug exposure in rhesus monkeys.
目的研究恒河猴注射促黃體激素釋放激素-綠膿杆菌外毒素A(GP38)後體内中和抗體的産生及其對藥物暴露水平的影響。
The recombinant virus can generate neutralizing antibody with the high level in a mouse which aims to wild human type-3 adenovirus.
該重組病毒可以在小鼠體内産生針對野生人3型腺病毒的高水平中和抗體。
This vaccine's prevention effect take the neutralizing antibody level and the protection ratio as the major targets or quotas.
該疫苗的預防效果以中和抗體水平和保護率為主要指标。
The envelope glycoprotein HA on influenza virus is the most important antigen that initiates neutralizing antibody response in host and also involved in viral replication.
流感病毒的血凝素基因(HA)編碼的血凝素是産生中和抗體的重要抗原,并在病毒的受體識别和複制中起重要作用。
Thus, we did some researches about neutralizing antibody against WSSV and viral protein involved in infection using phage display technology.
為此,本研究應用噬菌體展示技術對WSSV的中和抗體及感染相關蛋白進行了研究。
Conclusion The clinical trials indicated that the purified rabies vaccine prepared from Vero cells only showed slight side reaction and had good neutralizing antibody response.
該疫苗經臨床觀察和中和抗體測定的結果顯示,副反應輕微,且有良好的中和抗體應答。
A rise in neutralizing antibody in the convalescent serum has been revealed to occur only in one half of the infections.
研究(實驗)解釋康複病人血清内中和性抗體的增加,僅見于半數感染病例中。
During early stage of CIA development, expression of VEGF in the joint increases and VEGF is expressed biologically active and can be inhibited by anti VEGF neutralizing antibody.
CIA形成的早期關節組織内可能産生大量的VEGF ,并以較強的生物活性形式存在,能被抗VEGF中和抗體抑制。
Neutralizing antibody against rabies virus was demonstrated in the sera collected from 39 cases of corroborative rabid patients.
對有确診依據的39例狂犬病患者進行抗狂犬病中和抗體檢測。
MethodsThe effects of AGE, CML, S100 protein and neutralizing antibody against RAGE on MCP-1 gene and protein expressions were examined by RT-PCR and ELISA in mouse podocytes.
方法以RT-PCR和ELISA的方法檢測AGE、羰甲基化白蛋白(CML)、S100蛋白和RAGE中和抗體對小鼠足細胞的MCP-1的基因和蛋白質表達的影響。
Of three forms of S recombinant proteins, only S or S1 protein induced neutralizing antibody responses, antibody titer was increased by S protein immunization.
其中,僅S和S1蛋白重組質粒能夠誘導中和抗體的産生,以S蛋白的效價為高。
Conclusion The HI antibody positive rate of measles vaccine decreased as time goes on . However , the neutralizing antibody positive rate of it was still satisfied.
結論麻疹疫苗HI抗體陽性率隨免疫時間推移降低,但細胞中和抗體陽性率仍較理想。
Further tests on the rats showed that a neutralizing antibody which targeted CXCL5 was able to reduce the sensitivity to pain caused by the UVB irradiation.
之後在大鼠身上的進一步研究顯示,一種被CXCL5定位的中和抗體能減輕紫外線照射後皮膚對疼痛的敏感性。
The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.
白化的孟加拉虎接種疫苗後不能産生CDV中和抗體。
Neutralizing antibody;
中和抗體;
After incubation of virus with its antiserum, the antiserum that can inhibit virus binding ability to the cells should contain neutralizing antibody.
當病毒與抗血清保溫後,抑制病毒與細胞的吸附能力的抗血清中應含有中和抗體。
Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.
白化的孟加拉虎接種疫苗後不能産生CDV中和抗體。
Blocking effect of HPO by HPO neutralizing antibody was utilized and the changes of cell proliferation was observed.
利用HPO特異性抗體封閉HPO的作用,觀察封閉HPO的作用後,細胞增殖的變化。
The tested monkey can produce neutralizing antibody with singularity, and the neutralizing antibody with singularity can stop the infection of SV40virus to cell culturing matter during the test.
本發明免疫猴可産生特異性中和抗體,産生的特異性中和抗體在體外實驗中可使SV40病毒失去對細胞培養物的感染性。
Methods We collected randomly 269 serum samples among 0-39 years healthy population and detected the polio neutralizing antibody in Ansai County.
方法隨機抽樣确定安塞縣0~39歲人群269名,采集血清标本,檢測脊灰抗體。
Aim: To study the effect of neutralizing antibody on the therapeutic effect of IFNa-2b.
目的:了解幹擾素中和抗體對幹擾素療效的影響。
Neutralizing antibody had a small drop . did not disappear in patients.
中和抗體效價稍有下降,但未發現中和抗體消失者。
Newly published research reveals how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus.
新近的研究顯示了一個廣泛中和的HIV抗體實際是怎樣用部分多糖外殼去鍵合病毒的。
Doing the virus regression test while determining rabies virus neutralizing-antibody, the results showed that the actual dose of virus used for challenge was not consistent with the theoretical dose.
狂犬病毒中和試驗的病毒回歸試驗表明,病毒攻毒液的實際劑量與理論劑量不完全一緻。
TNF induced in the cell culture was demonstrated by monoclone antibody neutralizing test.
誘生出的TNF通過單克隆抗體中和試驗得到确證。
The neutralizing index of the antibody induced by recombinant viccinia virus was slightly lower than that induced by HAAg.
由重組病毒産生的抗體中和指數比甲肝病毒産生者略低。
中和抗體(neutralizing antibody)是免疫系統産生的一類特異性抗體,能夠通過結合病原體(如病毒、細菌等)表面的關鍵抗原表位,直接阻斷其感染宿主細胞的能力。這類抗體的核心功能體現在“中和”作用上,即通過空間位阻或構象改變,阻止病原體與宿主細胞受體的結合,例如新冠病毒的刺突蛋白與人體ACE2受體的結合過程。
根據世界衛生組織的定義,中和抗體在疫苗效力評估中具有重要指示意義,其血清濃度常被用作衡量免疫保護力的生物标志物。美國國立衛生研究院的研究顯示,針對HIV病毒的中和抗體不僅能阻止病毒入侵,還能通過抗體依賴性細胞毒性作用(ADCC)清除被感染的細胞。
在臨床應用層面,單克隆中和抗體藥物已成功用于埃博拉病毒、狂犬病毒等急性感染的治療。中國疾病預防控制中心2023年發布的《中和抗體臨床應用指南》指出,這類生物制劑在暴露後預防中可使狂犬病發病率降低95%以上。值得注意的是,中和抗體的持續時間因病原體而異,例如麻疹疫苗誘導的中和抗體可維持數十年,而呼吸道合胞病毒(RSV)的中和抗體水平通常在數月内顯著下降。
中和抗體(neutralizing antibody)是一種能夠阻止病原體(如病毒、細菌)感染宿主細胞的抗體。以下是詳細解釋:
AI理性設計技術正推動廣譜中和抗體的開發,可同時針對多種病毒亞型(如甲型流感病毒Group 1和Group 2)。
如需進一步了解具體研究案例,可參考來源1(海詞詞典)和來源3(PNAS論文)的詳細描述。
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