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neutralizing antibody是什麼意思,neutralizing antibody的意思翻譯、用法、同義詞、例句

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  • [免疫] 中和抗體

  • 例句

  • Also, neutralizing antibody of paired sera were detected.

    此外,還測定患兒雙份血中病毒的中和抗體增長。

  • In 11 patients of PM/DM with muscular pain , the positive rates of enterovirus RNA were 72.73% , higher than that of neutralizing antibody test (18.18% ).

    在有肌肉酸痛症狀的患者(11例)中,腸道病毒RNA的陽性率為72.73%,明顯高于中和抗體的陽性率(18.18% );

  • Aim To investigate the effects of grown releasing hormone-pseudomonas aeruginosa exotoxin 38(GP38) neutralizing antibody on drug exposure in rhesus monkeys.

    目的研究恒河猴注射促黃體激素釋放激素-綠膿杆菌外毒素A(GP38)後體内中和抗體的産生及其對藥物暴露水平的影響。

  • The recombinant virus can generate neutralizing antibody with the high level in a mouse which aims to wild human type-3 adenovirus.

    該重組病毒可以在小鼠體内産生針對野生人3型腺病毒的高水平中和抗體。

  • This vaccine's prevention effect take the neutralizing antibody level and the protection ratio as the major targets or quotas.

    該疫苗的預防效果以中和抗體水平和保護率為主要指标。

  • The envelope glycoprotein HA on influenza virus is the most important antigen that initiates neutralizing antibody response in host and also involved in viral replication.

    流感病毒的血凝素基因(HA)編碼的血凝素是産生中和抗體的重要抗原,并在病毒的受體識别和複制中起重要作用。

  • Thus, we did some researches about neutralizing antibody against WSSV and viral protein involved in infection using phage display technology.

    為此,本研究應用噬菌體展示技術對WSSV的中和抗體及感染相關蛋白進行了研究。

  • Conclusion The clinical trials indicated that the purified rabies vaccine prepared from Vero cells only showed slight side reaction and had good neutralizing antibody response.

    該疫苗經臨床觀察和中和抗體測定的結果顯示,副反應輕微,且有良好的中和抗體應答。

  • A rise in neutralizing antibody in the convalescent serum has been revealed to occur only in one half of the infections.

    研究(實驗)解釋康複病人血清内中和性抗體的增加,僅見于半數感染病例中。

  • During early stage of CIA development, expression of VEGF in the joint increases and VEGF is expressed biologically active and can be inhibited by anti VEGF neutralizing antibody.

    CIA形成的早期關節組織内可能産生大量的VEGF ,并以較強的生物活性形式存在,能被抗VEGF中和抗體抑制。

  • Neutralizing antibody against rabies virus was demonstrated in the sera collected from 39 cases of corroborative rabid patients.

    對有确診依據的39例狂犬病患者進行抗狂犬病中和抗體檢測。

  • MethodsThe effects of AGE, CML, S100 protein and neutralizing antibody against RAGE on MCP-1 gene and protein expressions were examined by RT-PCR and ELISA in mouse podocytes.

    方法以RT-PCR和ELISA的方法檢測AGE、羰甲基化白蛋白(CML)、S100蛋白和RAGE中和抗體對小鼠足細胞的MCP-1的基因和蛋白質表達的影響。

  • Of three forms of S recombinant proteins, only S or S1 protein induced neutralizing antibody responses, antibody titer was increased by S protein immunization.

    其中,僅S和S1蛋白重組質粒能夠誘導中和抗體的産生,以S蛋白的效價為高。

  • Conclusion The HI antibody positive rate of measles vaccine decreased as time goes on . However , the neutralizing antibody positive rate of it was still satisfied.

    結論麻疹疫苗HI抗體陽性率隨免疫時間推移降低,但細胞中和抗體陽性率仍較理想。

  • Further tests on the rats showed that a neutralizing antibody which targeted CXCL5 was able to reduce the sensitivity to pain caused by the UVB irradiation.

    之後在大鼠身上的進一步研究顯示,一種被CXCL5定位的中和抗體能減輕紫外線照射後皮膚對疼痛的敏感性。

  • The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.

    白化的孟加拉虎接種疫苗後不能産生CDV中和抗體。

  • Neutralizing antibody;

    中和抗體;

  • After incubation of virus with its antiserum, the antiserum that can inhibit virus binding ability to the cells should contain neutralizing antibody.

    當病毒與抗血清保溫後,抑制病毒與細胞的吸附能力的抗血清中應含有中和抗體。

  • Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.

    白化的孟加拉虎接種疫苗後不能産生CDV中和抗體。

  • Blocking effect of HPO by HPO neutralizing antibody was utilized and the changes of cell proliferation was observed.

    利用HPO特異性抗體封閉HPO的作用,觀察封閉HPO的作用後,細胞增殖的變化。

  • The tested monkey can produce neutralizing antibody with singularity, and the neutralizing antibody with singularity can stop the infection of SV40virus to cell culturing matter during the test.

    本發明免疫猴可産生特異性中和抗體,産生的特異性中和抗體在體外實驗中可使SV40病毒失去對細胞培養物的感染性。

  • Methods We collected randomly 269 serum samples among 0-39 years healthy population and detected the polio neutralizing antibody in Ansai County.

    方法隨機抽樣确定安塞縣0~39歲人群269名,采集血清标本,檢測脊灰抗體。

  • Aim: To study the effect of neutralizing antibody on the therapeutic effect of IFNa-2b.

    目的:了解幹擾素中和抗體對幹擾素療效的影響。

  • Neutralizing antibody had a small drop . did not disappear in patients.

    中和抗體效價稍有下降,但未發現中和抗體消失者。

  • Newly published research reveals how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus.

    新近的研究顯示了一個廣泛中和的HIV抗體實際是怎樣用部分多糖外殼去鍵合病毒的。

  • Doing the virus regression test while determining rabies virus neutralizing-antibody, the results showed that the actual dose of virus used for challenge was not consistent with the theoretical dose.

    狂犬病毒中和試驗的病毒回歸試驗表明,病毒攻毒液的實際劑量與理論劑量不完全一緻。

  • TNF induced in the cell culture was demonstrated by monoclone antibody neutralizing test.

    誘生出的TNF通過單克隆抗體中和試驗得到确證。

  • The neutralizing index of the antibody induced by recombinant viccinia virus was slightly lower than that induced by HAAg.

    由重組病毒産生的抗體中和指數比甲肝病毒産生者略低。

  • 專業解析

    中和抗體(neutralizing antibody)是免疫系統産生的一類特異性抗體,能夠通過結合病原體(如病毒、細菌等)表面的關鍵抗原表位,直接阻斷其感染宿主細胞的能力。這類抗體的核心功能體現在“中和”作用上,即通過空間位阻或構象改變,阻止病原體與宿主細胞受體的結合,例如新冠病毒的刺突蛋白與人體ACE2受體的結合過程。

    根據世界衛生組織的定義,中和抗體在疫苗效力評估中具有重要指示意義,其血清濃度常被用作衡量免疫保護力的生物标志物。美國國立衛生研究院的研究顯示,針對HIV病毒的中和抗體不僅能阻止病毒入侵,還能通過抗體依賴性細胞毒性作用(ADCC)清除被感染的細胞。

    在臨床應用層面,單克隆中和抗體藥物已成功用于埃博拉病毒、狂犬病毒等急性感染的治療。中國疾病預防控制中心2023年發布的《中和抗體臨床應用指南》指出,這類生物制劑在暴露後預防中可使狂犬病發病率降低95%以上。值得注意的是,中和抗體的持續時間因病原體而異,例如麻疹疫苗誘導的中和抗體可維持數十年,而呼吸道合胞病毒(RSV)的中和抗體水平通常在數月内顯著下降。

    網絡擴展資料

    中和抗體(neutralizing antibody)是一種能夠阻止病原體(如病毒、細菌)感染宿主細胞的抗體。以下是詳細解釋:

    一、核心機制

    1. 中和作用:通過結合病原體表面的關鍵蛋白(如病毒刺突蛋白),阻止其與宿主細胞受體結合。例如,流感病毒的中和抗體會靶向血凝素蛋白,抑制病毒進入細胞。
    2. 功能特點:不同于其他抗體僅标記病原體,中和抗體可直接使病原體失去感染能力。

    二、應用領域

    1. 抗病毒治療:廣泛用于HIV、流感、新冠病毒等病毒感染的治療和預防。
    2. 疫苗研發:疫苗的有效性常通過誘導中和抗體的水平來評估。

    三、技術進展

    AI理性設計技術正推動廣譜中和抗體的開發,可同時針對多種病毒亞型(如甲型流感病毒Group 1和Group 2)。

    四、補充說明

    如需進一步了解具體研究案例,可參考來源1(海詞詞典)和來源3(PNAS論文)的詳細描述。

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