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hepatic encephalopathy是什麼意思,hepatic encephalopathy的意思翻譯、用法、同義詞、例句

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  • [内科] 肝性腦病

  • 例句

  • Combination Therapy for Hepatic Encephalopathy?

    肝性腦病聯合治療?

  • This article discusses on the pathogenesis of hepatic encephalopathy.

    本文就對肝性腦病的發病機制進行綜述。

  • Objective:To investigate the alkalosis and hypoxemia in patients with liver cirrhosis accompanied by hepatic encephalopathy(HE).

    目的:探讨肝硬化患者并發肝性腦病(HE)時的堿中毒與低氧血症。

  • Objective To observe the efficacy of coenzyme complex in treating hepatic encephalopathy.

    目的觀察複合輔酶治療肝性腦病的臨床療效。

  • Results Single factor analysis showed that hepatic encephalopathy, blood ammonia level and operative methods were related with abnormal mental status after liver transplantation.

    結果:單因素分析顯示,術前合并肝性腦病、術前血氨水平及手術方式與術後精神狀态異常的發生有關。

  • Methods The clinical data of 4 patients with fulminant hepatic failure and hepatic encephalopathy treated with OLT were retrospectively analyzed.

    方法回顧性分析4例暴發性肝衰肝性腦病病人行肝移植手術治療的臨床資料。

  • Objective To discuss the early diagnostic value of evoke potential detection of subclinical hepatic encephalopathy (SHE).

    目的探讨誘發電位對亞臨床肝性腦病的早期診斷價值。

  • Objective To investigate the effects of Qingkai Granule on neural evoked potential in subclinical hepatic encephalopathy(SHE) rats.

    目的探讨清開顆粒對亞臨床肝性腦病(SHE)大鼠神經誘發電位的影響。

  • Conclusions The changes of the amino acid receptor gated ion channel currents play an important role in the pathogenesis of hepatic encephalopathy.

    結論氨基酸受體門控性離子通道電流改變在肝性腦病發生中起一定作用。

  • AIM The effect of brain-gut peptide(BGP)on the occurence and development of hepatic encephalopathy(HE)was stu***d.

    目的:為探讨腦腸肽(BGP)在肝性腦病(HE)發生和發展中的作用。

  • In the patient and the animal model of hepatic encephalopathy, the function of glutamate neurotransmitter is bad, and receptor binding site is reductive and even lack.

    肝性腦病患者及動物模型中谷氨酸神經遞質功能不良,其受體結合位點減少甚至缺失。

  • Conclusion Plasma exchange is an effective method to hepatic encephalopathy.

    結論血漿置換治療肝性腦病療效肯定。

  • Hepatology Digest: For the current state of affairs can you please summarize the main benefits and drawbacks of current therapeutic avenues for hepatic encephalopathy (HE).

    《國際肝病》:能否請您就目前的形勢總結下現今肝性腦病治療途徑中主要有哪些利弊?

  • Objective To explore the imbalance of the intestinal flora on ammonia concentrations in experimental rats with hepatic encephalopathy.

    目的探讨肝性腦病實驗大鼠腸道菌群失調對血氨濃度的影響。

  • Objective To study Psychometric measures and ERP-P300 in diagnosis of minimal hepatic encephalopathy.

    目的研究簡易智能測試和事件相關電位P300(ERP-P300)對輕微肝性腦病的診斷。

  • Objective:To study the relationship between free radical and hepatic encephalopathy after TIPSS by examing MDA in hepatic tissue and SOD in blood.

    目的:測定TIPSS前後犬肝組織丙二醛(MDA)和犬靜脈血************歧化酶(SOD)的變化,分析TIPSS術後氧自由基變化與肝性腦病的關系。

  • Acute liver failure leads to hepatic encephalopathy.

    急性肝功能衰竭可導緻肝性腦病。

  • Methods The clinical data of 48 cases with hepatic encephalopathy in this hospital were reviewed.

    方法48例肝性腦病患者的臨床資料進行回顧性分析。

  • Objective To investigate MRI characteristics, brain perfusion pattern in basal ganglion and extrapyramidal symptoms in patients with subclinical hepatic encephalopathy (SHE).

    目的研究亞臨床期肝性腦病(SHE)患者的MRI特征、基底節區的腦血流灌注模式及錐體外系損傷的表現。

  • Objective To observe the clinical efficacy of lactulose in different courses for patients with subclinical hepatic encephalopathy(SHE).

    目的觀察乳果糖對亞臨床肝性腦病(SHE)不同療程的療效。

  • CONCLUSION : Qingchang Mixture is of better efficacy, convenient administration and lower cost for hepatic encephalopathy compared to lactulose.

    結論:與口服乳果糖相比,“清腸合劑”灌腸用于治療肝性腦病具有療效優、給藥方便、費用低廉等特點。

  • The results showed that the serum PRL levels ip both chronic hepatitis and hepatocirrhosis were higher than that in normal person, especially markedly higher in hepatic encephalopathy.

    結果表明慢性肝炎和肝硬化血清PRL水平均高于正常,其中尤以肝性腦病患者最為顯著。

  • Objective To explore the effects of the changes of the amino acid receptor gated ion channel currents on the pathogenesis of hepatic encephalopathy (HE).

    探讨氨基酸受體門控性離子通道電流改變在肝性腦病(HE)發生中的作用。

  • Objectives: The aim of this study is to evaluate the therapeutic effectiveness of plasma adsorption with HA microporous resin in patients of severe hepatitis with hepatic encephalopathy.

    目的觀察HA中性大孔樹脂血漿吸附治療重型肝炎肝性腦病的治療效果,探讨肝性腦病新的治療方法。

  • Evaluation for possible hepatic encephalopathy is crucial in the physical examination in the patient with suspected liver disease.

    在可疑肝髒疾病患者中通過體格檢查評估可能的肝性腦病是很艱難的。

  • 專業解析

    肝性腦病(Hepatic Encephalopathy, HE)是一種由嚴重肝功能障礙或門體分流引起的、以代謝紊亂為基礎的神經精神綜合征。其核心病理機制是肝髒解毒功能衰竭,導緻毒性物質(尤其是氨)在體内蓄積,并通過血液循環進入大腦,幹擾中樞神經系統的正常功能。

    核心病理機制與誘因:

    1. 氨中毒學說:肝髒無法将腸道吸收的氨(主要來自蛋白質代謝和細菌分解)充分轉化為尿素,導緻高氨血症。過量的氨穿過血腦屏障,幹擾腦細胞能量代謝和神經遞質平衡(如抑制興奮性神經傳遞,增強抑制性神經傳遞)。
    2. 神經遞質紊亂:除氨外,其他物質如γ-氨基丁酸(GABA)、内源性苯二氮卓類物質、芳香族氨基酸代謝産物(如假性神經遞質)的失衡也參與發病,導緻神經抑制增強。
    3. 炎症反應:全身性炎症和氧化應激可協同氨的毒性作用,破壞血腦屏障完整性,放大神經損害。
    4. 常見誘因:消化道出血(增加腸道氨負荷)、感染(增加炎症和代謝需求)、電解質紊亂(如低鉀、低鈉)、腎衰竭(減少氨排洩)、便秘、高蛋白飲食、不當使用鎮靜劑或利尿劑等均可誘發或加重HE 。

    臨床表現(West-Haven分級标準):

    診斷依據:

    治療原則:

    1. 消除誘因:積極治療消化道出血、感染、糾正電解質紊亂等 。
    2. 減少氨的産生與吸收:
      • 乳果糖/乳梨醇:作為一線藥物,在結腸被細菌分解産生有機酸,降低腸道pH值,抑制産氨菌生長,促進氨轉化為铵離子排出,并刺激排便 。
      • 利福昔明:腸道不吸收的抗生素,抑制産氨菌群 。
      • 低蛋白飲食(急性期):減少氨來源,首選植物蛋白(支鍊氨基酸含量高,産氨少),病情穩定後逐漸增加至適量。
    3. 促進氨的代謝:L-鳥氨酸-L-天冬氨酸(LOLA) 可促進尿素循環和谷氨酰胺合成以清除氨 。
    4. 支持治療與重症管理:維持水電解質平衡、營養支持,IV級患者需重症監護,必要時考慮人工肝支持或肝移植評估 。

    來源依據:

    1. 美國肝病研究學會(AASLD)及歐洲肝病學會(EASL)相關臨床實踐指南(2021年更新)對肝性腦病的定義、病理生理、診斷和治療有權威闡述。
    2. 國際知名醫學期刊《Journal of Hepatology》發表的綜述詳細探讨了氨代謝紊亂、神經炎症及神經遞質改變在HE中的作用(2023年)。
    3. 肝髒病學核心教材《Sherlock's Diseases of the Liver and Biliary System》系統描述了HE的臨床表現、分級(West-Haven标準)、診斷流程和治療策略(第13版,2024年)。

    網絡擴展資料

    肝性腦病(Hepatic Encephalopathy,HE)是一種由嚴重肝病或門體靜脈分流引起的神經系統功能紊亂綜合征,其核心特征為代謝紊亂導緻的中樞神經系統異常。以下是詳細解釋:

    1.定義與别稱

    2.病因

    3.臨床表現

    4.發病機制

    5.分類

    補充說明

    肝性腦病的診斷需結合肝病史及神經精神評估,治療重點在于糾正代謝異常和去除誘因。如需進一步了解具體病例或治療方案,可參考臨床指南或權威醫學文獻。

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