[生化] 競争性抑制；競争性抑制作用
The inhibition kinetic constant about competitive and non-competitive inhibition is figured out by calculating the substrate concentration on the same speed point.
競争性抑制和非競争性抑制通過求解等速點底物濃度的方法求解抑制常數。
Special competitive inhibition experiment demonstrated that foreign special DNA fragment inhibits the binding of the transcription factors with homologous fragments.
特異性競争抑制試驗表明外源性特異DNA片段能抑制相同片段與轉錄因子的結合。
In the competitive inhibition experiment, it showed that rapamycin and FK506 could bind this protein competitively and rapamycin had better binding capacity than FK506.
競争性抑制實驗顯示雷帕黴素與FK506和該蛋白質的結合存在競争性，且雷帕黴素與該蛋白質的結合能力比FK506強。
Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to cause interaction in coadministration.
而且CYP2D6能被多種藥物競争性抑制和誘導，藥物聯用時易産生相互作用。
METHODS The paratope mapping of antibo***s was determined by competitive inhibition in radioimmunoassay and the sequences of variable regions among the antibo***s were compared.
應用放射免疫競争抑制試驗測定抗體的配位特異性，并對抗體的可變區序列進行比較。
Competitive inhibition between methane and propene was minimized by physical separation of the regeneration and epoxidation.
将再生和環氧化過程分開進行，以減小甲烷和丙烯的競争抑制。
QU exhibited competitive inhibition of CYP3A2 dextromethorphan N-demethylation reaction and expressed noncompetitive inhibition of CYP2E1 chlorzoxazone-6-hydroxylation reaction.
槲皮素競争性抑制CYP3A2右美沙芬N脫甲基反應，非競争性抑制CYP2E1氯唑沙宗6羟化反應。
COMPETITIVE INHIBITION Competitive inhibitors compete with substrate for an enzyme's active site, lowering the enzyme's likelihood of binding substrate and slowing the observed reaction velocity.
競争性抑制競争性抑制劑與底物競争酶的活性部位，降低酶的約束力基闆的可能性，并觀察到的反應速 度放緩。
The effects of competitive product inhibition are shown to increase the substrate concentration in the carrier, and, additionally, to increase the effectiveness factors slightly.
産物競争性抑制的存在将增加載體顆粒内的底物濃度，對效率因子的影響較小。
A kinetics model was developed for predicting and simulating immobilized cellulase performance, which follows Michaelis_Menten kinetics with competitive product inhibition.
建立了固定化纖維素酶的反應動力學模型，該模型以米氏方程為基礎并考慮了産物競争性抑制的影響。
Kinetic stu***s showed that the mechanism of tyrosinase inhibition of both mono-demethoxycurcumin and carboxylized curcumin belongs to non-competitive type inhibition.
抑制動力學研究表明，單去*********姜黃素及帶羧基的姜黃素衍生物對酪氨酸酶的抑制均屬于非競争性抑制類型。
Kinetic stu***s of AG114 inhibition on recombinant human CK2 showed that the inhibition was mixed competitive with GTP and noncompetitive with casein.
AG114對重組人CK2的動力學研究表明：它與GTP呈混合競争性抑制作用，與酪蛋白呈非競争性抑制作用。
Kinetic stu***s of AG34 on recombinant human CK2 showed that the inhibition was mixed (competitive is dominant) with GTP and noncompetitive with casein.
AG34對重組人CK2的動力學研究表明：它與GTP呈現以競争性為主的混合型抑制作用，與酪蛋白呈非競争性抑制作用。
Kinetic stu***s of AG1112 on recombinant human CK2 showed that the inhibition was mixed(competitive is dominant) with GTP and noncompetitive with casein.
AG1112對重組人CK2的動力學研究表明：它與GTP和酪蛋白分别呈混合性和非競争性抑制作用。
It has been found that the coupling process is more effective for eliminating the product noncompetitive inhibition compared with the competitive one.
結果表明，該耦合過程對産物非競争性抑制的消除效果要優于競争性抑制。
The inhibition of AG372 on recombinant human CK2 was competitive with GTP and noncompetitive with casein.
AG372對重組人CK2的動力學研究表明：它與GTP呈競争性抑制作用，與酪蛋白呈非競争性抑制作用。
Kinetic analysis revealed that the inhibition on chymotrypsin by S-24 enzyme inhibitor is competitive with respect to the substrate.
動力學研究表明S-24酶抑制劑抑制糜蛋白酶，對底物酪蛋白、血紅蛋白的關系均為竟争性抑制。
Competitive kinetics Kinetic stu***s can be used to determine the type and potency of inhibition for an unknown inhibitor.
競争動力學可用于動力學研究，以确定一個未知抑制劑抑制的類型和效力。
Methods: The colloidal gold strip for specific sulfadimidine was developed successfully on the basis of competitive inhibition immunochromatography mechanism.
方法：應用競争抑制免疫層析原理，研制磺胺*********嘧啶膠體金試紙條。
競争性抑制（competitive inhibition）是酶動力學中的一種抑制作用機制，指抑制劑分子與酶的正常底物在結構上相似，兩者通過競争結合酶的活性位點，從而降低酶的催化效率。這種抑制作用的特點體現在米氏方程的變化上：抑制劑的加入會使底物的表觀米氏常數（(Km)）增大，而最大反應速率（(V{max})）保持不變，公式可表示為： $$ V0 = frac{V{max}[S]}{K_m(1 + [I]/K_i) + [S]} $$ 其中([I])為抑制劑濃度，(K_i)為抑制常數。
一個經典案例是磺胺類藥物對細菌二氫葉酸合成酶的抑制。磺胺分子與底物對氨基苯甲酸（PABA）結構相似，通過占據酶的活性中心阻斷細菌葉酸合成途徑，從而抑制其增殖。在代謝調控中，此類抑制作用常見于反饋抑制機制，例如終産物通過競争性抑制調控代謝通路關鍵酶活性。
現代藥物研發高度依賴該原理，如他汀類藥物通過競争性抑制HMG-CoA還原酶降低膽固醇合成。這種靶向作用機制因其可逆性和特異性，成為設計選擇性抑制劑的重要策略。
競争性抑制（competitive inhibition）是酶催化反應中的一種抑制作用機制，其核心特征如下：
作用機制 抑制劑與底物結構相似，兩者競争結合酶的活性位點。當抑制劑占據活性位點時，底物無法與酶結合，導緻催化反應速率降低。這種抑制可通過增加底物濃度來逆轉。
動力學參數變化
經典案例 丙二酸對琥珀酸脫氫酶的抑制是典型例子。丙二酸與底物琥珀酸結構相似，通過競争結合酶活性位點阻斷三羧酸循環。
應用領域 藥物開發中廣泛應用此原理，例如：
該機制揭示了生物分子間相互作用的特異性，為代謝調控和藥物靶點設計提供了理論基礎。
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